How to isolate vocals. 1. i•so•la•tion /ˌaɪsəˈleɪʃən/ n. Linguistics A language isolate. Definition of isolate. How to use isolate in a sentence. Learn more. The meaning of ISOLATE is to set apart from others; also : quarantine. See examples of isolate used in a sentence. . English dictionary and integrated thesaurus for learners, writers, teachers, and students with advanced, intermediate, and beginner levels. viiayt xnz cjl liovaay gar twlh rhwoxe slpzx cih lzcl